Alvin Shi, Ph.D.

Year of Graduation: 



Prof. Manolis Kellis

Current Position: 

Bioinformatics and Data Scientist, Grail, Inc.

Doctoral Thesis Title: Computational Dissection and prediction of cancer immunotherapy response

Publications while at MIT:

Evolution of delayed resistance to immunotherapy in a melanoma responder.

Liu D, Lin JR, Robitschek EJ, Kasumova GG, Heyde A, Shi A, Kraya A, Zhang G, Moll T, Frederick DT, Chen YA, Wang S, Schapiro D, Ho LL, Bi K, Sahu A, Mei S, Miao B, Sharova T, Alvarez-Breckenridge C, Stocking JH, Kim T, Fadden R, Lawrence D, Hoang MP, Cahill DP, Malehmir M, Nowak MA, Brastianos PK, Lian CG, Ruppin E, Izar B, Herlyn M, Van Allen EM, Nathanson K, Flaherty KT, Sullivan RJ, Kellis M, Sorger PK, Boland GM.Nat Med. 2021 Jun;27(6):985-992. doi: 10.1038/s41591-021-01331-8. Epub 2021 May 3.PMID: 33941922 Free PMC article.


Plasma-derived extracellular vesicle analysis and deconvolution enable prediction and tracking of melanoma checkpoint blockade outcome.

Shi A, Kasumova GG, Michaud WA, Cintolo-Gonzalez J, Díaz-Martínez M, Ohmura J, Mehta A, Chien I, Frederick DT, Cohen S, Plana D, Johnson D, Flaherty KT, Sullivan RJ, Kellis M, Boland GM.Sci Adv. 2020 Nov 13;6(46):eabb3461. doi: 10.1126/sciadv.abb3461. Print 2020 Nov.PMID: 33188016 Free PMC article.