Cassandra Schaening Burgos, Ph.D.

Year of Graduation: 



Prof. Wendy Gilber & Prof. Gene-Wei Li

Current Position: 

Scientist I, Remix Therapeutics

Doctoral Thesis Title: Transcriptome-wide pseudouridine profiling reveals modification of critical E. coli mRNAs


Publications while at MIT:

Transcriptome-wide mapping reveals a diverse dihydrouridine landscape including mRNA.

Draycott AS, Schaening-Burgos C, Rojas-Duran MF, Wilson L, Schärfen L, Neugebauer KM, Nachtergaele S, Gilbert WV.PLoS Biol. 2022 May 24;20(5):e3001622. doi: 10.1371/journal.pbio.3001622. eCollection 2022 May.PMID: 35609439 Free PMC article.


Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing.

Martinez NM, Su A, Burns MC, Nussbacher JK, Schaening C, Sathe S, Yeo GW, Gilbert WV.Mol Cell. 2022 Feb 3;82(3):645-659.e9. doi: 10.1016/j.molcel.2021.12.023. Epub 2022 Jan 19.PMID: 35051350


Pseudouridine site assignment by high-throughput in vitro RNA pseudouridylation and sequencing.

Martinez NM, Schaening-Burgos C, Gilbert WV.Methods Enzymol. 2021;658:277-310. doi: 10.1016/bs.mie.2021.06.026. Epub 2021 Jul 30.PMID: 34517951 Free PMC article.


mRNA structure determines modification by pseudouridine synthase 1.

Carlile TM, Martinez NM, Schaening C, Su A, Bell TA, Zinshteyn B, Gilbert WV.Nat Chem Biol. 2019 Oct;15(10):966-974. doi: 10.1038/s41589-019-0353-z. Epub 2019 Sep 2.PMID: 31477916 Free PMC article.


Messenger RNA modifications: Form, distribution, and function.

Gilbert WV, Bell TA, Schaening C.Science. 2016 Jun 17;352(6292):1408-12. doi: 10.1126/science.aad8711.PMID: 27313037 Free PMC article. Review.