Grace Zheng, Ph.D.

Year of Graduation: 



Prof. Phillip Sharp and Prof. Chris Burge

Current Position: 

Director of Computational Biology and Machine Learning, ArsenalBio, San Francisco, CA.

Doctoral Thesis Title: Exploring the regulatory rolesroles of microRNAs in mammalian development

Publications while at MIT:

Genome-wide impact of a recently expanded microRNA cluster in mouse.

Zheng GX, Ravi A, Gould GM, Burge CB, Sharp PA.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15804-9. doi: 10.1073/pnas.1112772108. Epub 2011 Sep 12.PMID:21911408 Free PMC Article


MicroRNAs can generate thresholds in target gene expression.

Mukherji S, Ebert MS, Zheng GX, Tsang JS, Sharp PA, van Oudenaarden A.

Nat Genet. 2011 Aug 21;43(9):854-9. doi: 10.1038/ng.905.PMID:21857679 Free PMC Article


A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells.

Zheng GX, Ravi A, Calabrese JM, Medeiros LA, Kirak O, Dennis LM, Jaenisch R, Burge CB, Sharp PA.

PLoS Genet. 2011 May;7(5):e1002054. doi: 10.1371/journal.pgen.1002054. Epub 2011 May 5. PMID:21573140 Free PMC Article


Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs.

Leung AK, Young AG, Bhutkar A, Zheng GX, Bosson AD, Nielsen CB, Sharp PA.

Nat Struct Mol Biol. 2011 Feb;18(2):237-44. doi: 10.1038/nsmb.1991. Epub 2011 Jan 23. Erratum in: Nat Struct Mol Biol. 2011 Sep;18(9):1084. PMID:21258322 Free PMC Article


Dynamic regulation of miRNA expression in ordered stages of cellular development.

Neilson JR, Zheng GX, Burge CB, Sharp PA.

Genes Dev. 2007 Mar 1;21(5):578-89.PMID:17344418 Free PMC Article