Michelle Chan Ph.D.

Year of Graduation: 



Prof. Aviv Regev

Current Position: 

Assistant Professor, Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics, Princeton University

Thesis Title: DNA methylation in early mammalian development


Publications while at MIT:

1. DNA methylation dynamics of the human preimplantation embryo.

Smith ZD, Chan MM, Humm KC, Karnik R, Mekhoubad S, Regev A, Eggan K, Meissner A.Nature. 2014 Jul 31;511(7511):611-5. doi: 10.1038/nature13581. Epub 2014 Jul 23.PMID: 25079558 Free PMC article.


2. Correction: Evolutionary principles of modular gene regulation in yeasts.

Thompson DA, Roy S, Chan M, Styczynski MP, Pfiffner J, French C, Socha A, Thielke A, Napolitano S, Muller P, Kellis M, Konieczka JH, Wapinski I, Regev A. Elife. 2013 Jul 2;2:e01114. doi: 10.7554/eLife.01114.PMID: 23840936 Free PMC article.



3. Mouse ooplasm confers context-specific reprogramming capacity.

Chan MM, Smith ZD, Egli D, Regev A, Meissner A. Nat Genet. 2012 Sep;44(9):978-80. doi: 10.1038/ng.2382. Epub 2012 Aug 19.PMID: 22902786 Free PMC article.


4. A unique regulatory phase of DNA methylation in the early mammalian embryo.

Smith ZD, Chan MM, Mikkelsen TS, Gu H, Gnirke A, Regev A, Meissner A. Nature. 2012 Mar 28;484(7394):339-44. doi: 10.1038/nature10960.PMID: 22456710 Free PMC article.