Robin Friedman Ph.D.

Year of Graduation: 

2011

Advisors/Lab: 

Prof. Chris Burge and Prof. David Bartel

Current Position: 

Senior Director of Computational Biology at Dragonfly Therapeutics Inc., Cambridge, MA

Dragonfly Therapeutics, Inc. 

Thesis Title:  The specificity and evolution of gene regulatory elements 

Publications while at MIT:

1. MicroRNA target finding by comparative genomics.

Friedman RC, Burge CB.

Methods Mol Biol. 2014;1097:457-76. doi: 10.1007/978-1-62703-709-9_21. Review. PMID:24639172

2. Direct measurement of DNA affinity landscapes on a high-throughput sequencing instrument.

Nutiu R, Friedman RC, Luo S, Khrebtukova I, Silva D, Li R, Zhang L, Schroth GP, Burge CB.

Nat Biotechnol. 2011 Jun 26;29(7):659-64. doi: 10.1038/nbt.1882.PMID:21706015 Free PMC Article

 

3. Hepatitis C virus infection and hepatic stellate cell activation downregulate miR-29: miR-29 overexpression reduces hepatitis C viral abundance in culture.

Bandyopadhyay S, Friedman RC, Marquez RT, Keck K, Kong B, Icardi MS, Brown KE, Burge CB, Schmidt WN, Wang Y, McCaffrey AP.

J Infect Dis. 2011 Jun 15;203(12):1753-62. doi: 10.1093/infdis/jir186. PMID:21606534 Free PMC Article

4. Formation, regulation and evolution of Caenorhabditis elegans 3'UTRs.

Jan CH, Friedman RC, Ruby JG, Bartel DP.

Nature. 2011 Jan 6;469(7328):97-101. doi: 10.1038/nature09616. Epub 2010 Nov 17.PMID:21085120 Free PMC Article

5. Most mammalian mRNAs are conserved targets of microRNAs.

Friedman RC, Farh KK, Burge CB, Bartel DP.

Genome Res. 2009 Jan;19(1):92-105. doi: 10.1101/gr.082701.108. Epub 2008 Oct 27.PMID:18955434 Free PMC Article