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Neurodegenerative disease can progress in newly identified patterns
Read more: Neurodegenerative disease can progress in newly identified patternsA machine-learning method finds patterns of health decline in ALS, informing future clinical trial designs and mechanism discovery. The technique also extends to Alzheimer’s and Parkinson’s. Neurodegenerative diseases — like amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), Alzheimer’s, and Parkinson’s — are complicated, chronic ailments that can present with a variety of symptoms, worsen at different rates, and have…
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When cells’ tiny differences have far-reaching implications
Read more: When cells’ tiny differences have far-reaching implicationsPhoto: M.Scott Brauer Alex Shalek’s technologies for single-cell RNA profiling can help dissect the cellular bases of complex diseases around the globe. Within a given tissue or organ, cells may appear very similar or even identical. But at the molecular level, these cells can have small differences that lead to wide variations in their functions.…
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How a shape-shifting receptor influences cell growth
Read more: How a shape-shifting receptor influences cell growthImage: Courtesy of the researchers Insight into the way the EGF receptor sends signals into cells could help researchers design new cancer drugs that target this protein. Receptors found on cell surfaces bind to hormones, proteins, and other molecules, helping cells respond to their environment. MIT chemists have now discovered how one of these receptors…
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