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CSB Thesis Defense: Cameron Flower (White Lab)

Posted
April 25, 2024

CSB PhD Candidate: Cameron Flower

Faculty Advisor: Prof. Forest White

Date: Friday April 26, 2024

Time: 1:00 PM EST

Thesis title: Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition

Abstract:

Therapeutics targeting oncogenic kinases have offered longer survival and superior quality of life for cancer patients with particular malignancies compared to the preceding standard of care. However, many patients still fail to show a clinically meaningful response to kinase inhibitors prescribed on the basis of tumor genotype, and nearly all responsive patients eventually develop resistance, limiting the curative potential of these agents. A more complete understanding of the molecular basis underlying therapy failure is required for designing new agents and combinations with improved...

News

Forbes Israel 30 Under 30-Liyam Chitayat

Posted
April 8, 2024

L. Chitayat| Photo: Zeno Fox

Age: 20 >> PhD student at MIT

Even before she turned 20, Liyam Chitayat began her doctorate at MIT, one of the leading academic research institutions in the US and the world, and won the Hertz Award for Research Excellence - the most...

News

Deciphering the cellular mechanisms behind ALS

Posted
March 6, 2024

Professor Ernest Fraenkel has decoded fundamental aspects of Huntington’s disease and glioblastoma, and is now using computation to better understand amyotrophic lateral sclerosis.

At a time in which scientific research is increasingly cross-disciplinary, Ernest Fraenkel, the Grover M. Hermann Professor in Health Sciences and Technology in MIT’s Department of Biological Engineering, stands out as both a very early adopter of drawing from different scientific fields and a great advocate of the practice today.

When Fraenkel’s students find themselves at an impasse in their work, he suggests they approach their problem from a different angle or look for inspiration in a completely unrelated field.

“I think the thing that I always come...

News

Dealing with the limitations of our noisy world

Posted
March 1, 2024

Tamara Broderick uses statistical approaches to understand and quantify the uncertainty that can affect study results.

 

Tamara Broderick first set foot on MIT’s campus when she was a high school student, as a participant in the inaugural Women’s Technology Program. The monthlong summer academic experience gives young women a hands-on introduction to engineering and computer science.

What is the probability that she would return to MIT years later, this time as a faculty member?

That’s a question Broderick could probably answer quantitatively using Bayesian inference, a statistical approach to probability that tries to quantify uncertainty by continuously updating one’s assumptions as new data are obtained.

In her lab at MIT, the newly tenured...