Thanks to continued advances in genetic sequencing, scientists have identified virtually every A, T, C, and G nucleotide in our genetic code. But to fully understand how the human genome encodes us, we need to go one step further, mapping the function of each base.
Image Credit: Page Lab
Research in Evolutionary and Computational Biology leverages large-scale genomic, transcriptomic and related data across diverse species to unlock the molecular mechanisms of life.
Student: Amanda Kedaigle
Title: Integrating Omics Data: A new Software Tool and its Use in Implicating Therapeutic Targets in Huntington's Disease
New discovery suggest that all life may share a common design principle.
Student: Vincent Xue
Title: Modeling and Designing Bcl-2 Family Protein Interactions Using High-Throughput Interaction Data
Drug that targets a key cancer protein could combat leukemia and other types of cancer.
MIT biologists have designed a new peptide that can disrupt a key protein that many types of cancers, including some forms of lymphoma, leukemia, and breast cancer, need to survive.
The new peptide targets a protein called Mcl-1, which helps cancer cells avoid the cellular suicide that is usually induced by DNA damage. By blocking Mcl-1, the peptide can force cancer cells to undergo programmed cell death.
Student: Peter Freese
Title: "Biochemical and Functional Characterization of Human RNA Binding Proteins"