Image Credit:Geoff Fudenberg and Leonid Mirny
Research in Molecular Biophysics and Structural Biology at MIT studies fundamental properties of molecules and systems, often by integrating computational thinking, engineering designs, and biophysical insights.
In lab tests, virus-like DNA structures coated with viral proteins provoke a strong immune response in human B cells.
By folding DNA into a virus-like structure, MIT researchers have designed HIV-like particles that provoke a strong immune response from human immune cells grown in a lab dish. Such particles might eventually be used as an HIV vaccine.
Rapid imaging method could help reveal how conditions such as autism affect brain cells.
Our brains contain trillions of synapses — the connections that transmit messages from neuron to neuron. Within these synapses are hundreds of different proteins, and dysfunction of these proteins can lead to conditions such as schizophrenia and autism.
Researchers have devised a faster, more efficient way to design custom peptides and perturb protein-protein interactions.
Researchers develop a method to investigate how bacteria respond to starvation and to identify which proteins bind to the "magic spot" - ppGpp.
New approach generates a wider variety of protein sequences optimized to bind to drug targets.
Designing synthetic proteins that can act as drugs for cancer or other diseases can be a tedious process: It generally involves creating a library of millions of proteins, then screening the library to find proteins that bind the correct target.