Study in worms reveals gene loss can lead to accumulation of waste products in cells.
Photo Credit: Yilmaz lab
Embryonic stem cells – and induced pluripotent stem cells – retain the ability to differentiate into any cell type in the body. Research in Stem Cell and Developmental Systems Biology seeks to understand the rules for cellular differentiation and dedifferentiation, to understand how cells and tissues interact during development to specify structures and systems in the adult, and to explore the regenerative and therapeutic potential of stem and stem-cell-derived cells.
Study finds that major vault protein is needed for homeostatic plasticity.
In a new study of one of the most common genetic causes of autism, neuroscientists at MIT’s Picower Institute for Learning and Memory have identified a molecular mechanism that appears to undermine the ability of neurons in affected mice to properly incorporate changes driven by experience. The findings, published in the Journal of Neuroscience, suggest that a particular gene, MVP, is likely consequential in people with 16p11.2 deletion syndrome.