Researchers have devised a faster, more efficient way to design custom peptides and perturb protein-protein interactions.
Cover Image Credit: Keating Lab
Image Credit: Lu Lab
Research in Synthetic Biology and Biological Design emphasizes elucidating engineering principles behind biological systems for creating novel therapeutics and biomaterials.
New 3-D imaging technique can reveal, much more quickly than other methods, how neurons connect throughout the brain.
Researchers develop a method to investigate how bacteria respond to starvation and to identify which proteins bind to the "magic spot" - ppGpp.
New approach generates a wider variety of protein sequences optimized to bind to drug targets.
Designing synthetic proteins that can act as drugs for cancer or other diseases can be a tedious process: It generally involves creating a library of millions of proteins, then screening the library to find proteins that bind the correct target.
PhotMacArthur "geniuses" in machine learning and synthetic biology to serve as faculty co-leads; Nobel laureate to chair advisory board of new reasearch center.
By manipulating DNA, researchers are trying to create microbes that, once ingested, work to treat a rare genetic condition - a milestone in synthetic biology.
Ultra-low power sensors carrying genetically engineered bacteria can detect gastric bleeding.
MIT researchers have built an ingestible sensor equipped with genetically engineered bacteria that can diagnose bleeding in the stomach or other gastrointestinal problems.
Synthetic Biologist hopes to develop treatments for cancer and other diseases.
In high school and college, Timothy Lu spent a lot of time programming computers. But as his college graduation approached, he turned his attention toward programming biological systems. The field of synthetic biology was just beginning to emerge, and he wanted to be part of it.
Student: Vincent Xue
Title: Modeling and Designing Bcl-2 Family Protein Interactions Using High-Throughput Interaction Data
Drug that targets a key cancer protein could combat leukemia and other types of cancer.
MIT biologists have designed a new peptide that can disrupt a key protein that many types of cancers, including some forms of lymphoma, leukemia, and breast cancer, need to survive.
The new peptide targets a protein called Mcl-1, which helps cancer cells avoid the cellular suicide that is usually induced by DNA damage. By blocking Mcl-1, the peptide can force cancer cells to undergo programmed cell death.