By manipulating DNA, researchers are trying to create microbes that, once ingested, work to treat a rare genetic condition - a milestone in synthetic biology.
Cover Image Credit: Keating Lab
Image Credit: Lu Lab
Research in Synthetic Biology and Biological Design emphasizes elucidating engineering principles behind biological systems for creating novel therapeutics and biomaterials.
Ultra-low power sensors carrying genetically engineered bacteria can detect gastric bleeding.
MIT researchers have built an ingestible sensor equipped with genetically engineered bacteria that can diagnose bleeding in the stomach or other gastrointestinal problems.
Synthetic Biologist hopes to develop treatments for cancer and other diseases.
In high school and college, Timothy Lu spent a lot of time programming computers. But as his college graduation approached, he turned his attention toward programming biological systems. The field of synthetic biology was just beginning to emerge, and he wanted to be part of it.
Student: Vincent Xue
Title: Modeling and Designing Bcl-2 Family Protein Interactions Using High-Throughput Interaction Data
Drug that targets a key cancer protein could combat leukemia and other types of cancer.
MIT biologists have designed a new peptide that can disrupt a key protein that many types of cancers, including some forms of lymphoma, leukemia, and breast cancer, need to survive.
The new peptide targets a protein called Mcl-1, which helps cancer cells avoid the cellular suicide that is usually induced by DNA damage. By blocking Mcl-1, the peptide can force cancer cells to undergo programmed cell death.
New technique 3-D prints programmed cells into living devices for first time.
Novel structures made with DNA scaffolds could be used to create solar-powered materials.
Researchers at MIT have developed a synthetic gene circuit that triggers the body’s immune system to attack cancers when it detects signs of the disease.
The circuit, which will only activate a therapeutic response when it detects two specific cancer markers, is described in a paper published today in the journal Cell.
Biological engineers identify genes that protect against protein linked to Parkinson's disease.
Using a modified version of the CRISPR genome-editing system, MIT researchers have developed a new way to screen for genes that protect against specific diseases.
CRISPR is normally used to edit or delete genes from living cells. However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson’s disease.