2014

Doctoral Thesis Title: Understanding regulation of mRNA by RNA binding proteins Publications while at MIT:  1. RNA Bind-n-Seq: Measuring the Binding Affinity Landscape of RNA-Binding Proteins. Lambert NJ, Robertson AD, Burge CB.Methods Enzymol. 2015;558:465-493. doi: 10.1016/bs.mie.2015.02.007. Epub 2015 May 12.PMID: 26068750 Free PMC article. 2. RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins.…

Doctoral Thesis Title: Pervasive degeneracy and epistasis in a protein-protein interface Publications while at MIT:  1. The small membrane protein MgrB regulates PhoQ bifunctionality to control PhoP target gene expression dynamics. Salazar ME, Podgornaia AI, Laub MT. Mol Microbiol. 2016 Nov;102(3):430-445. doi: 10.1111/mmi.13471. Epub 2016 Aug 25. PMID: 27447896 2. Protein evolution. Pervasive degeneracy and epistasis in a protein-protein interface.…

Doctoral Thesis Title:  Multivariate methods for the statistical analysis of hyperdimensional high-content screening data  Publications While at MIT: 1.A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. Rameseder J, Krismer K, Dayma Y, Ehrenberger T, Hwang MK, Airoldi EM, Floyd SR, Yaffe MB. J Biomol Screen. 2015 Sep;20(8):985-97. doi: 10.1177/1087057115583037. Epub 2015 Apr 27. PMID:25918037 Free…

Wu Lab Website Doctoral Thesis Title: The mechanism and function of pervasive noncoding transcription in the mammalian genome Publications while at MIT:  1. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko…