2018

Doctoral Thesis Title: Modeling and Designing Bc1-2 Family Protein Interactions Using High-Throughput Interaction Data Publications while at MIT: Peptide design by optimization on a data-parameterized protein interaction landscape. Jenson JM, Xue V, Stretz L, Mandal T, Reich LL, Keating AE. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10342-E10351. doi: 10.1073/pnas.1812939115. Epub 2018 Oct 15.…

Doctoral Thesis Title: Intergrating Omics Data: a new software tool and its sse in implicating therapeutic targets in Huntington’s Disease Publications while at MIT:  1.Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington’s disease mice. Kedaigle AJ, Reidling JC, Lim RG, Adam M, Wu J, Wassie B, Stocksdale JT, Casale MS,…

biobot Analytics VCGC Interview with Mariana Doctoral Thesis Title:  Analysis of fecal biomarkers to impact clinical care and public health  Publications while at MIT:  Salt-responsive gut commensal modulates TH17 axis and disease. Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Haase S, Mähler A, Balogh A, Markó L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Frätzer C, Krannich A, Gollasch M, Grohme…

Doctoral Thesis Title: Biochemical and functional characterization of human RNA binding proteins Publications while at MIT: 1.Expanded encyclopaedias of DNA elements in the human and mouse genomes. ENCODE Project Consortium, Moore JE, Purcaro MJ, Pratt HE, Epstein CB, Shoresh N, Adrian J, Kawli T, Davis CA, Dobin A, Kaul R, Halow J, Van Nostrand EL, Freese P,…